Sobre o projeto
The overall aim of the project is to study crosstalk of peptide-receptor systems in metazoans using the malaria model and to characterise the role of mosquito orphan receptors in its physiology, life cycle and parasite infection. This project intends to break new ground in the current understanding about the emergence and co-evolution of metazoan endocrine peptide-receptor pairs that may result from a host-parasite interaction of orphan family 2 G-protein coupled receptors (GPCRs) with peptides of human blood.
Functional characterization of orphan family 2 GPCR receptors in the malaria model
Atividades
The project will make use of publicly available molecular and functional tools for mosquito and will use a series of comparative physiological assays, computing skills and functional approaches to: i) Isolate and characterise the mosquito family 2 GPCRs; ii) Determine the importance and role of family 2 GPCRs during the mosquito life cycle; iii) Characterise potential crosstalk between mosquito receptors and human peptides; iv) Identify potential endogenous ligands and v) Investigate receptor function in malaria parasite infection.
Publicações
Coordenação do CCMAR
Membros do CCMAR
Financiamento
