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Bone disorders affect millions of people worldwide and current treatments have a limited efficacy often accompanied by side effects. The discovery of novel bone anabolic compounds with either pharmaceutical or nutraceutical value is thus needed. The zebrafish has recently emerged as a model for human bone diseases but also as a system for the screening of compounds that would treat or prevent these diseases. Beyond the technical advantages over traditional models (e.g. rodents), the high similarity of targets, physiology, drug metabolism and pharmacology in comparison to humans further highlights the potential of zebrafish as a robust model for drug screenings. The BIOSKEL lab (CCMAR, University of Algarve) has developed several zebrafish assays to evaluate the osteogenic potential of natural or synthetic compounds. Within the scope of the training workshop here presented, we propose to share both the theoretical and practical knowledge required to go through all the steps of those procedures.
Main topics:
- Basis of zebrafish biology and husbandry
- Current knowledge on drug screenings
- Ways of exposing zebrafish to experimental compounds
- Imaging of bone structures and morphometric analysis
- Assessment of compound osteogenic and regenerative potential
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